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The BakerGordon Syndrome Foundation was founded to help families affected by this syndrome make connections with one another. BakerGordon Syndrome BAGOS also known as SYT1associated neurodevelopmental disorder SYT1 Syndrome is a rare genetic disorder caused by mutations in the Synaptotagmin1 SYT1 gene. SYT1 is a vital protein that regulates the triggering of neurotransmitter release at the synapse. The mutation of the SYT1 in patients commonly causes intellectual disabilities visual abnormalities low muscle tone and more.