A 7-year-old boy is brought to clinic with a several-month history of easy bruising, fatigue, and recurrent bone pain. Physical exam reveals marked splenomegaly. Laboratory studies show anemia and thrombocytopenia. A splenectomy is performed, and H&E staining reveals numerous enlarged macrophages with abundant, pale, fibrillary cytoplasm, described as having a “crumpled tissue paper” appearance, primarily within the red pulp. Which enzyme deficiency is responsible for this finding? Take the assessment: https://zurl.co/lvOi4 (fb)

Transforming care starts here! Join us for the #PathVisions25 Keynote and discover how patient-centric pathology is making a difference. Hear from patient champion Deedee O'Brien and pioneering pathologist Dr. Lija Joseph as they share their unique experiences and insights on empowering patients through understanding. Don't miss their session, "Diagnosis to Decision – A Pathway through Pathology," on Monday, Oct 6 from 9:35–10:35 AM. Learn more & register: https://zurl.co/ZyZtt (fb)