One Health is a collaborative, multi-sectoral, and trans-disciplinary approach, working locally, regionally, nationally, and globally, to achieve optimal health and well-being of all animals, people, plants and their shared environment, recognizing their inextricable inter-connections. The Charter of the One Health Commission is to ‘Educate’ and ‘Create’ networks to improve health outcomes and well-being of humans, animals and plants and to promote environmental resilience through a collaborative, global One Health approach. The Commission works strategically to connect One Health Stakeholders, to Educate globally about One Health and One Health issues, and to nourish future leaders of One Health Sciences.