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WELCOME TO THE Greater Wyoming Valley Chamber of Commerce Meet Our Members Get Involved Community Calendar Login The Greater Wyoming Valley Chamber of Commerce formerly known as the Greater WilkesBarre Chamber of Commerce is a memberdriven organization representing hundreds of businesses and organizations focused on helping members grow and succeed in Northeastern PA. Nestled in the heart of Northeastern Pennsylvania the region offers yearround recreation and entertainment a growing economy an old fashioned sense of neighborhood and easy access to major cities. Our Priorities Connect the Valley Learn how we connect you with resources in the community to start grow and develop your business. Innovate the Valley Learn how we use our Certified Economic Development organization to support business and industry.