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Committed to Advancing Basic Clinical Research on RLS Welcome to the IRLSSG The International Restless Legs Syndrome Study Group IRLSSG is an organization of professionals committed to advancing basic and clinical research on Restless Legs Syndrome RLS. Their mission includes the cooperative planning implementation analysis and reporting of multicenter studies with an international emphasis. The IRLSSG may also pursue other research activities and education related to RLS and to other related entities such as periodic limb movements PLM. To this end the IRLSSG aims to advance knowledge about the causes pathogenesis and clinical impact of RLS and related disorders.