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News Blog Newly Diagnosed Donate Learn Care Research About Community Giving More Join us for2025 SciFam Congenital Muscular Dystrophy CMD is a group of rare genetic disorders defined by muscle weakness at or soon after birth. Mutations in one of more than 30 genes cause muscle tissue to break down faster than the body can repair it. A person with CMD may have a variety of neurological and physical impairments including the inability to walk respiratory weakness scoliosis joint contractures feeding and cardiac complications and for some profound cognitive impairment. There are currently no FDA approved treatments for CMD.