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Light Up Cincinnati On March 21st downtown Cincinnati will be lighting up BLUE and YELLOW at dusk for World Down Syndrome Day. Learn more World Down Syndrome Day 5K10KKids Fun Run Each year ourWorld Down Syndrome Day 5K 10K Kids Fun Runtakes place the Sunday after World Down Syndrome Day. Learn more and register Our Mission The mission of the Down Syndrome Association of Greater Cincinnati is to empower individuals educate families enhance communities and together celebrate the extraordinary lives of people with Down syndrome. New Expectant Parents Congratulations.