LMI Our Impact Research Funding To Date 8000000 in research grants Research Publications 20 publications resulting from 45 funded projects and presentations conducted by 36 investigators Research Network 40 investigatorsover 10 countries represented Complex Lymphatic Anomaly CLA is an umbrella term encompassing four overlapping but distinct rare diseases of the lymphatic system Gorham Stout Disease GSD Generalized Lymphatic Anomaly GLA Kaposiform Lymphangiomatosis KLA and Central Conducting Lymphatic Anomaly CCLA. CLAs are characterized by growth of abnormal lymphatic tissue involving both soft tissue and bone leading to chronic and debilitating conditions that can be fatal. The LMI is a 501c3 organization that was established in 2010 to support research that drives our understanding of the pathobiology and genetics of CLAs. The institute also supports and funds clinical and translational research to better define the impact of CLAs on our patients testing of new therapies and finding biomarkers of disease activity and treatment response.