serving those affected by pseudoxanthoma elasticum PXE International was founded in 1995 to promote research and support individuals affected by pseudoxanthoma elasticum (PXE). We work on behalf of individuals and their families to improve quality of life through advancing research, educating clinicians and supporting individuals. PXE International is the prime force in conducting basic and clinical research and providing financial support for applied translational research, product development, and treatment development for pseudoxanthoma elasticum(PXE).