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Speed the search for treatments The largest international Usher syndrome database in the world Announcing new partnership to support clinical trial enrollment for a potential therapy for USH2Amediated retinitis pigmentosa What is Usher Syndrome. Usher syndromeis the most common genetic cause of combined deafness and blindness. Usher syndrome USH is a rare inherited condition passing from parents to children that impacts three major senses in the body vision hearing and balance. There are three clinical types of Usher syndrome Type 1 usually causes profound deafness at birth vestibular balance dysfunction and progressive vision loss due to retinitis pigmentosa Type 2 usually causes moderate to severe hearing loss at birth and progressive vision loss Type 3 usually causes later onset progressive hearing loss and progressive vision loss.