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Welcome to the Horn Lake Chamber of Commerce Join Become a Member Whats New Calendar of Events Directory Find a Business Our MissionTo be The intersection of commerce and community. Our MissionTo be The intersection of commerce and community. Located in the heart of DeSoto County Horn Lake is a thriving hub where businesses flourish and community thrives. With a welcoming atmosphere exceptional opportunities for growth and a strong sense of connection Horn Lake is the perfect place to live work and grow.