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Welcome to the UNESCO Cascade Head Biosphere Region The Salmon River and its restored estuary Crescent Cove and the beginning of the Marine Reserve at Cascade Head The native prairie meadows of Cascade Head stretch 2 miles out to sea The vibrant human communities of Otis and Lincoln City Oregon BISOPHERE BASICS. Details about Oregons last remaining UNESCO Biosphere Region. The Cascade Head Biosphere Region is a 102110 acre site designated originally in 1976 on the central Oregon Coast by the United Nations Man and Biosphere Program and reauthorized to our current footprint in 2017. It has within its boundaries the Cascade Head Scenic Research Area Cascade Head Experimental Forest the Cascade Head Preserve and the Cascade Head Marine Reserve and Marine Protected Areas.