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Doing Business A robust economy has made the Springfield Region an attractive environment for a diverse spectrum of businesses from Fortune 500s to private ventures. The Region The Springfield Region spans 10 counties in Southwest Missouri supplying a skilled workforce and stability to foster the growth of regional companies. Industries Springfield is nationally recognized for its low cost of doing business making the region the perfect climate for a wide variety of companies and industries. See why With a MSA population of 462369 Springfield is nationally recognized for its low cost of living and low cost of doing business.