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Lake Santa Fe Santa Fe Lake Dwellers Association Main menu Santa Fe Lake Dwellers Association Protecting the Gem of North Florida Santa Fe Lake Dwellers Association Inc. is a nonprofit grassroots organization of friends and neighbors dedicated to the enjoyment and protection of Lake Santa Fe in north central Florida. Lake Santa Fe is designated by the State of Florida as an Outstanding Florida Water which according to the Florida Department of Environmental Protection means it is worthy of special protection because of its natural attributes. The lake covers approximately 5856 acres and along with the 7046acre Santa Fe Swamp at the north end of the lake is considered the headwaters of the Santa Fe River the largest tributary of the mighty Suwannee River.