Currently, there is no treatment for IRF2BPL-Related Disorder. Tough Genes is here to change that! Tough Genes is a 501c3 nonprofit organization. Founded by parents of a child with IRF2BPL-Related Disorder, Tough Genes is a 501c3 nonprofit organization dedicated to advancing scientific knowledge and medical understanding of the IRF2BPL gene. Our mission is based upon raising awareness and funds for IRF2BPL-Related Disorder research. We strive to transform lives by driving breakthroughs in science, increasing awareness, and securing the resources necessary to find treatment and improve the quality of life for those impacted by this disorder.