HomeTicketsnbspEvent Gallery PLEX Informer News Sign Up Formnbsp Places of InterestBrownfieldContact Us PLEX Calendar The PlymouthExchange Neighborhood Association Together We Can Make A Difference Plymouth Exchange Neighborhood PlymouthExchange or PLEX for short is a neighborhood centered on the parallel roadways of South Plymouth Avenue and Exchange Street. Parts of PLEX are included in the Third Ward Historic District. It is a largely residential area where University of Rochester students and employees mingle with workingclass families. Running along the southeastern border of PLEX is the Genesee River Trail between Exchange St.