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HOME WHAT IS PWS ABOUT US RESOURCES RESPITE TRAINING TEAM DONATE EVENTS BLOG CONTACT More What is PWS. PraderWilli syndrome PWS is a complex genetic disorder resulting from abnormality on the 15th chromosome. PWS causes low muscle tone short stature if not treated with growth hormone cognitive deficits problem behaviors and most notable a chronic feeling of hunger which when coupled with a metabolism. What We Do UPWSA is a 501c3 nonprofit organization providing support to individuals diagnosed with PWS their families communities and care providers.