The Highland Commerce Guild Inc is a nonprofit organization based in Louisville, Kentucky, designated as a 501(c)(6) business league. It focuses on fostering economic development and community enhancement within the Louisville Highlands neighborhood, supporting small businesses and residents in the area. The organization aims to assist in business and community problem solving and contributes to maintaining the Highlands as a vibrant, attractive place for commerce and living.

The Guild hosts monthly meetings, typically held on the last Wednesday of each month, which are designed to engage local business owners and community members in collaborative efforts to support and grow the local economy. These meetings are accessible both in-person and online, facilitating wider participation. In addition to networking, they provide a platform for discussing initiatives to improve the business climate and community welfare in the Highlands.

Among its activities, the Highland Commerce Guild organizes events such as Louisville's Bardstown Road Aglow, which promotes the local business district and enhances community involvement. The organization is involved in advocacy, education, and workforce development initiatives tailored to the needs of the local economy.

By working to create opportunities and raise awareness, the Highland Commerce Guild plays a key role in economic and community development within its region, ensuring the Louisville Highlands remain a desirable place to work, shop, and live.