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Your Custom Text Here Inflammatory processes keep us alive. But when they becomes chronic or run out of control they can lead to debilitating and lifethreatening conditions anywhere in the body involving multiple systems and myriad clinical presentations that can change in type and severity over time. Mast Cell Activation Syndrome Mast Cell Activation Syndrome MCAS may be at the root of widespread chronic debilitating illness. It is an emerging illness not that it is new but rather in that it has only recently been named and become the subject of attempts to define diagnostic criteria and the medical community is only just beginning to be aware of its existence.