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Issue published March 3 2025Previous issue Go to section On the cover Carnitine palmitoyl transferase 1a regulates hematopoietic stem cell maintenance Li et al. report on the role of carnitine palmitoyl transferase 1a Cpt1a in maintaining stemness of hematopoietic stem cells and its regulation of mitochondrial metabolism by balancing fatty acid oxidation and glucosefueled oxidative phosphorylation. The cover art depicts the contrasting effects of fatty acids and highglucose concentrations on stem cell integrity. Pink droplets represent fatty acidenriched microenvironments where stem cells appear robust and stable.