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Upcoming Back to Business Grant Openings Chamber Events 2nd Desk Coworking About the Chamber Headquartered in Pikeville Kentucky the Southeast Kentucky Chamber of Commerce is a resource for businesses in Southeast Kentucky that is committed to improving the regional economy. We represent more than 500 member businesses and organizations across an eightcounty region including Floyd Johnson Knott Lawrence Letcher Magoffin Martin and Pike Counties. Our Impact The work that the Chamber and our members do impacts every industry in the region which in turn benefits both your business the community and the region at large. We hope you join our cause and invest in our organization because you are not just investing in a nonprofit you are strengthening the economy creating jobs and influencing our regions future.