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Marthasville Area Chamber of Commerce Membership Programs Events More MARTHASVILLE AREA CHAMBER OF COMMERCE WHO WE ARE The Marthasville Area Chamber of Commerce welcomes you to Marthasville Missouri one of the St. Louis areas most treasured communities. Located near the Missouri River just an hour outside of Downtown St. Louis Marthasvilles rich history and tightknit community make it the perfect place to live work and raise a family.